Dosage:
Adt:Usually 1gm daily by deep IM slow IV Inj over at least 2-4mins., or IV infusion. Severe infections, 2-4gm as asingle dose every 24 hrs.Gonarrhoea, single dose of 250mg by IM inj.Peri-op prophylaxis, 1gm as single IM or slow IV dose.Colorectal surgery,2gm by IM slow IV inj or inj or infusion with anaerobic antibacterial.Children:Usually 20-50mg/kg once daily by IM inj slow IV inj over at least 2-4 mins., or IV infusion.SEvere infections, up to max. 80mg/kg daily(max 50mg/kg in neonates).Doses over 50mg/kg to be given by slow IV infusion over at least 30 minutes

Precautions:
Administer cephalosporins cautiously to penicillin sensitive patients as there may be a partial crossalergenicity between the two.Cephalosporin may be nephrotoxic.Inflammatory reactions to parentral cephalosporins are common.Inject preparations for IM administration deep into the musculature

AdverseEffects:
Gl disturbances (nausea, vomiting, diorrhoea) and hypersensitivity phenomena.Eosinophilia, transient neutropenia, leukopenia, thrombocytopenia. Elevated SOPT and SGPT. Mild elevation in BUN. Headache, dizziness and paresthesia. Fever and dyspnea

Indication:
Severe respiratory and genitourinary tract, bone and joint, abdominal infections, sepsismeningitis

ContraIndication:
Hypersensitivity to cephalosporins or releated antibiotics