| Dosage: Adt: Duodenal And Gastric Ulcer:
150mg, Twice daily And 300mg,
at bedtime for four weeks or
300mg, twice daily; maintanence
150mg, at bedtime.Du with H.
Pylori: 300mg at bedtime for
4 weeks plus amoxycillin 750mg
three times daily And metronidazole
500mg three times daily for two
2 weeks. Prevention of NSAID
induced duodenal Ulcer: 150mg
twice daily. Reflux oesophagitis:
150mg twice daily or 300mg at
bedtime for up to 12 weeks. if
moderate to severe 150mg, four
times daily for up to 12 weeks.Children:
under 2 years not recommended,
over 2 years, Peptic ulcer only,
2-4mg/kg twice daily; max 300mg
daily. Inj:Adt: slow (Over a
period of 2 mins ) IV Inj of
50mg after dilution to a volume
of 20ml Per50mg dose; intermittent
IV infusion at a rate of 25mg
per hour for 2 hours; IM Inj
of 50mg (2ml) all may be repeated
every 6-8 hours.
Precautions: Exclude malignant disease,
before yreatment impaired
renal funcation , acute porphyria,
pregnancy, lactation.
AdverseEffects: Headache, dizziness, change
in liver funcation rarely
hapatitis, thrombocytopenia,
leucopenia, agranulocytosis,
pancytopenia, hypersensitivity,
confusion, breast symptoms
in men , reversible impotence,
rash, bradycardia, pancreatitis.
Indication: Treatement of Duodenal, begign
gastric And post-operative
ulceration, including that
due to NSAIDs. Prevention
of NASID induced duodenal
ulcers, duodenal ulcer associated
with H, Pylori. Oesophageal
reflux, reduced of gastric
acid chroic episodic dyspepsia,
Moderate to severs oesophagitis.
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