Dosage:
Average daily dose: 2 x 200 mg upto 400 mg can be given as a single dose in
the morning. In severe infections or infections with complicating factors
the dosage may be increased in individual cases to 800 mg daily (2 divided
doses). In patients with impaired renal function the initial dose is the
same as for patients with normal renal function. In patients undergoing
haemodialysis or peritoneal dialysis maintenance dose of 100 mg every 24
hours may be given. The duration of treatment should not exceed 2 months.
Recommended dose for prevention of infections in patients with a significant
reduction of resistance to infections is 400-600 mg daily.
Indications:
Infections of the
respiratory tract especially, if
caused by
Gram negative pathogen. Infections
of ear, nose and throat. Infections
of
the abdominal cavity. Infection
of the kidneys, urinary tract and
genital
organs. Infections of soft tissue
and skin. Infections of the bones
and
joints.
Contraindications/Precautions:
Hypersensitivity
to ofloxacin and
quinolones, epileptics, Children
or adolescents in the growth phase.
Pregnancy and lactation.
Adverse Reaction:
Hypersensitivity
reactions of the
skin, pruritus, vasculitis, oedema
of the face, swelling of the tongue,
difficulty in breathing followed
by shock, fever, erythema multiforme,
photosensitivity, effects on the
nervous system e.g sleep disorders,
headache, hallucinations, depression,
convulsions, disorders of muscular
coordination, paresthesia, visual
disorders, disorders of equilibrium,
giddiness, disorders of hearing,
taste and smell. Psychotic reactions,
agitation, anxiety, mental confusion
and restlessness, vivid dreaming,
effects on the gastrointestinal
tract e.g stomach upsets, abdominal
pain,
loss of appetite, nausea, vomiting
and diarrhoea. Impairment of renal
function e.g increase in serum
creatinine level, interstitial
nephritis.
Increased blood levels of hepatic
enzymes bilirubin. Muscle, tendon
and
joint symptoms and tachycardia.
Changes in blood picture (e.g.
leukopenia,
due to bone marrow depression)
agranulocytosis, thrombocytopenia.
ContraIndication:
History of epilepsy. Pregnancy,
lactation. Growing adolescents.
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