Dosage: Tabs:Adt:250-750mg twice daily usually for 5-10 days (3 days in acute cystitis). Gonorrhoea, single dose of 250mg. Prophylaxis single 750mg dose 60-90 minutes pre-op. Children:Only where benefit exceeds risk, 7.5-15mg/kg daily in two divided doses

Precautions: Epilepsy, history of CNS disorders. Severe renal impairment; reduce dose by half. Patients should be well hydrated. Patients with G-6-PD defects. Driving or operating machinery

AdverseEffects: Local irritation and pain at injection site. Gl disturbances. Dizziness, headache, tremor, confusion, convulsions, sleep disorders, pashes, photosensitivity, joint pain. Judgement and dexterity may be impairmed. Transient increase in serum creatinine. Haematological, hepatic and renal disturbances. Rarely, vasculitis, pseudomenbranous colitis, haemorrhagic bullae, stevens-Johnson and lyells syndrome, visual disturbances, transient hearing loss, tenosynovitis (discontinue treatment and rest limb), impaired taste and smell, tachycardia

Indication: UTI, respiratory, ENT, eye, skin and soft tissue, bone, joint, pelvic, biliary tract, intrabdominal and Gl infections. Gonorrhoea. Severe systemic infection. Gram-negative pneumonia (not for first the treatment in pneumococcal pneumonia). Prophylaxis in upper Gl surgery or endoscopy

ContraIndication: Children and growing adolescents except where benefit exceed risks. Pregnancy and lactation.